Morse's career has encompassed rock, country, funk, jazz, classical, and fusion of these musical genres. In addition to a thriving solo career, has been (and continues to be) a member of several renown bands.

The Dixie Dregs first effort for Capricorn, Free Fall, established Morse as an important newcomer to the fusion genre, and he was recognized for both his compositional skills (having written all 11 tracks) and his consummate musicianship. Although critically acclaimed as a pivotal jazz fusion album, the LP sold poorly.

What If was released to continued acclaim. Writing credits were more collaborative and the band's sound had matured into something a bit more than what defined fusion at the time. Southern rock, classical, folk and country elements combined to form a cohesive and complex pastiche of passionate and highly listenable music. Though supported by a tour, record sales remained flat, but gained Morse and the band an invitation to perform at Montreux Jazz Festival. The recorded performance was released the following year on Night of the Living Dregs. Capricorn went bankrupt shortly thereafter, though, and the Dixie Dregs were stranded without a label.

Arista Records then stepped in to sign the band to record three albums. Production control was handed to Morse, and Dregs of the Earth was released. All eight tracks were written by Morse, and the album peaked at number 27 on Billboard's Jazz Album Chart.

Arista became increasingly concerned about Dixie Dregs' commercial sales and pressured the band to change their name to simply "The Dregs" in an attempt to increase the band's visibility in the public eye. Unsung Heroes brought eight additional Morse compositions forward, but the name change did little to address Arista's worries. The Dregs were compelled to add lyrics to their next effort, appropriately titled Industry Standard, an apparent reference to executive and management oversight of their creative process.

Despite this, Morse's compositions on Industry Standard began to sound increasingly like his evolving solo work than Dregs' collaborations, and the album stood out to critical and public praise. Industry Standard was voted "Best Guitar LP" by readers of Guitar Player magazine in their annual reader's poll that year. Additionally, Morse was voted "Best Overall Guitarist" in the same poll, an honor that he would enjoy for five consecutive years (which ended his eligibility by retiring him into their "Gallery of Greats", a distinction shared only by Steve Howe of Yes.) Having fulfilled their commitment to Arista, the band succumbed to the pressures of constant gigging, and disbanded shortly.

Several years later, the group reunited for a tour featuring former members Morse, Morgenstein, Lavitz and Sloan. Their return was complemented by a "Best Of" release entitled Divided We Stand. Bassist Dave LaRue completed the line-up for a seven date tour culminating in the live album, Bring 'em Back Alive. Violinist Jerry Goodman, of The Mahavishnu Orchestra fame, filled in for Sloan, who was frequently absent as a result of his busy medical career. They signed a deal with a resurrected Capricorn Records for their first studio album in years entitled Full Circle.

Morse began putting together the Steve Morse Band, a trio with Jerry Peek (bass) and Doug Morgan (drums). Rod Morgenstein soon replaced Morgan, and they began recording The Introduction in September. The group had previously toured Germany with Morse conducting clinics, and the group was signed by Elektra Records, who released The Introduction mid-year. A second German tour followed, and Stand Up was released. This effort included guest vocalists and guitarists (Eric Johnson, Alex Ligertwood, Peter Frampton, Albert Lee, Van Temple), and violinist Mark O'Connor.

While on tour, Steve had supported several bands, including progressive rock trio, RUSH. Morse continued in the genre by joining KANSAS when they reformed in the late 1980s, replacing lead guitarist and songwriter, Kerry Livgren. His tenure with the band yielded two releases on MCA, Power and In the Spirit of Things. During this period, he co-wrote the band's last big hit (thus far), "All I Wanted," which reached the Billboard Top 20 and received heavy rotation on MTV. Morse left the band after touring the final album, but re-joined the band for a 1991 tour.

After KANSAS, Morse took a break from the music industry, and pursued another passion: flying. Steve worked professionally for several years as a commercial airline co-pilot, enjoying a break from the spotlight. Eventually, though, music came calling again.

Ritchie Blackmore left Deep Purple in the middle of their 1993 tour. Joe Satriani served as a short-term replacement to finish the tour. Afterwards, though, Steve Morse was asked to join the band as a permanent member (and continues to this day). Together, the band has, so far, released four studio and seven live albums.

In addition to playing with Deep Purple, and his other efforts; Morse, together with Jimmy Barnes, Bob Daisley, Lee Kerslake and Don Airey, formed Living Loud in 2003.

Steve begins 2009 with several new projects underway, including solo endeavors, collaborative projects, and continued work with Deep Purple.